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Bio-Synthesis/[Gln22] - beta - Amyloid (1 - 42), E22Q Dutch Mutation, human/0.5 mg/13798-005
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Bio-Synthesis/[Gln22] - beta - Amyloid (1 - 42), E22Q Dutch Mutation, human/0.5 mg/13798-005
市场价：
¥5200.00
美元价：
2600.00
产品分类：
电生理设备
公司分类：
Electrophysiological
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
[Gln22] - beta - Amyloid (1 - 42), E22Q Dutch Mutation, human
Sequence (1LC):
DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVVIA
Sequence (3LC):
NH2 - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Gln - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - COOH
Catalog :
13798-005
Unit:
0.5 mg
Price/Unit:
$260(For other quantities please Contact Us or call 972-420-8505)
Purity:
Purity > 95% by HPLC
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This peptide is a naturally occurring mutant form of the wild type (WT) beta-Amyloid 1 to 42 peptide. The E22Q "Dutch" mutant, also known as HCHWA-D, is caused by a point mutation in the beta-Amyloid encoding gene, with Glu replaced by Gln at position 22. Dutch E22Q mutation in beta-Amyloid causes familial cerebrovascular amyloidosis with abundant diffused amyloid plaque deposits. E22Q mutant and WT peptides are both stable in "collapsed coil" conformations. The E22Q fibrils are more toxic for vascular cells than the WT fibrils.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
4513.1 g/mol
Reference/Citations:
- Massi, F. and J. Straub Biophys. J. 81, 697 (2001);
- Muñoz, F. et al. J. Neurosci. 22, 3081 (2002);
- Davis, J. et al. J. Biol. Chem. 279, 20296
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Bio-Synthesis关于我们生物合成是为研究，诊断和治疗行业提供高质量核酸，肽和其他分子生物学产品的生物学合同制造商。生物合成已通过ISO 9001：2015认证，并遵循GLP和GMP准则。我们的解决方案有助于推进药物发现和生物医学研究。Bio-Synthesis成立于1984年，是一家位于德克萨斯州Lewisville的私有公司。定制肽合成自1984年以来，Bio-Synthesis一直为生命科学研究领域的客户提供定制肽合成服务。我们提供完整的肽合成服务，范围从原料API肽到高通量文库肽和阵列肽制备。进行定制肽合成以生产研究级或大量API多肽。我们专注于液相和固相Fmoc化学。液相肽合成用于合成非常短的肽（如二肽），而大规模固相肽合成非常适合于制备包括长，难和疏水性肽在内的生物活性肽。生物合成还为诊断和治疗应用提供了大量的肽修饰以及定制肽。
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